PROJECT

TNSL

 

Our goals:

  • To unveil the fundamental and universal principle for dynamics of biological structure and function.
  • To understand how biological and disease processes work based on such fundamental and universal laws.
  • To develop mathematical and computational methodologies for effectively and efficiently predicting future states of biological and disease processes.
  • To develop methodologies and tools for effectively and efficiently control by design biological and disease processes based on such predictions, and also to pre-empt and treat human diseases.

We undertake cross (X)-disciplinary approaches towards these goals by integrating concepts, methodologies and tools of Biology, Medical sciences, Mathematics, Engineering and Computational sciences: BioMEC-X.

Ultimately, our research is expected to contribute to realizing healthy and long-lasting life style in our society via “Virtual Live Clinics”.  The concept of “Virtual Live Clinics” is to allow everyone to monitor their currently health conditions, to obtain the forecast of their future health conditions, and to pre-empt and/or treat their conditions, at anytime and anywhere, all by themselves without going to hospitals or clinics. 

 

Unveiling the fundamental principles of biological dynamics

We conduct research to unveil the fundamental principles governing dynamics of diverse biological processes.  We measure and collect highly quantitative and integrated data for the biological processes that are inherently complex and dynamically behaving in space and time (i.e., 4D).  By analyzing such data, we uncover operating principles for these biological processes.  We also develop methodologies for controlling diverse biological processes by design based on such principles.  We are currently developing genetic and chemical methods that enable us to control such biological processes, by which we realize the design-based control of diverse and complex biological processes.

 

Unveiling the fundamental principles of disease dynamics

We conduct research to unveil the fundamental principles governing dynamics of diverse human disease processes.  We also develop therapeutics to pre-empt and treat human diseases by design based on such principles.  The most of the diseases that currently lack effective pre-emptive and treatment methods (e.g., heart diseases, brain diseases, lifestyle related diseases such as obesity, etc.) are caused by the complex interactions of many unknown multi-factors.  We identify each of such factors and uncover the integrative system by which such multi-factors interact to cause diseases.  By unveiling fundamental principles underlying such disease mechanisms, we develop effective pre-emptive and treatment methods for these diseases. 

 

Developing mathematical and computational methodologies and tools to predict and design biological and disease processes

We develop mathematical and computational methodologies and tools that can be applied to uncover central principles of biological and disease processes.  We also design methodological and therapeutic strategies to control biological processes and pre-empt and/or treat human diseases, respectively.  We develop highly sophisticated next-generation mathematical and computational methodologies and tools to enable precise forecasting of complex and dynamically behaving biological and disease processes.